Vitoli and Geroprotective Agents

By Eric Simard, PhD in biology and researcher (www.esimard.com).

Did you know that cutting-edge research on cellular longevity, carried out here in Quebec, has achieved the best results published to date in a high-level scientific journal? This research is even behind a range of high-quality natural products, produced here in Quebec: Vitoli^MD products. Let's delve into the history of this rapidly growing Quebec company, as recently highlighted by La Presse +.

The secret to longevity

An ambitious research program, carried out with the support of the Natural Sciences and Engineering Research Council of Canada (NSERC) for over 7 years, aims to increase cellular longevity. This research aims to identify natural molecules capable of modulating the metabolic pathways of primary aging. Recent discoveries have shown that it is possible to act on aging in a way that allows us to retain our abilities longer. The product Vitoli^MD Healthy Aging was developed specifically for this reason. We will come back to this.

It is important to know that aging is not only the result of wear and tear caused by oxidation. It took more than 10 years for a new theory to be defended by some scientists in the field in 2013, giving credit to a researcher who had put forward this hypothesis in 1957 (George C. Williams, 1926 – 2010: antagonistic pleiotropy (1957)). It was later renamed (Mikhail V. Blagosklonny): the hyperfunction theory.

Here are some explanations to help you better understand the scope of this research.

Gerosuppressive agents

From the moment these cellular mechanisms were linked to aging, in the mid-2000s, it became possible to search for molecules that could influence these processes. Some natural molecules have modulating effects on the mechanisms involved in the increased longevity of certain living beings. There are very few of them. Molecules capable of slowing down primary aging were initially called "caloric restriction mimetics."

We now call these molecules gerosuppressive agents; from the Greek "gero" meaning aging and "suppressor" for slowing down the process. This term better represents the objective pursued. Caloric restriction mimetics did not aim to reduce caloric intake, but to reproduce the benefits by slowing down primary aging.

Olive polyphenols

In 2013, a Spanish research group used the term ''gerosuppressors'' to categorize the multiple health benefits of olive polyphenols by linking them to aging processes. A second article, from another independent research group, confirmed this claim in 2019 through a very comprehensive literature review. Reviewing 194 scientific references, the team of de Pablos and collaborators (2019) summarized both the cellular mechanisms, animal models, and clinical studies conducted. These beneficial effects of olive polyphenols are at the origin of a large part of the health benefits of this oil, so important for the Mediterranean diet.

It is possible to extract these precious molecules directly from olives to guarantee the ingested quantity. With the help of cutting-edge extraction technology, Idunn Technologies uses an exclusive extract of olive polyphenols to add these benefits to each Vitoli product. The dose used corresponds to the daily dose consumed by followers of the Mediterranean diet in Europe. It is important to remember that Idunn Technologies, the company I created and which markets Vitoli^MD products, is behind the research program with Concordia University.

More effective Quebec products

Extensive analysis of the scientific literature led the European Union to approve a health claim for 5 mg of certain olive polyphenols. This is a claim for reducing the risk of cardiovascular diseases related to arterial blockage by oxidized bad cholesterol (what is known as atherosclerosis). It is on this health claim that we based the dosage of Provitol^MD Complex in Vitoli^MD products.

Thus, in each Vitoli^MD product (there are 12 different ones), you benefit from the presence of olive polyphenols, at the dose recommended by the European Union, to which are added plant extracts with the most scientific evidence for each of the targeted applications. Our in-depth knowledge of healthy longevity has led us to supplement certain formulas with vitamins and minerals when this contribution was deemed significant. For example, Vitoli^MD Immunity, in addition to containing plant extracts with the best non-specific antiviral effects, also contains the zinc and vitamin D3 necessary for better immune system health.

As mentioned at the beginning of the text, Vitoli^MD Healthy Aging was specifically developed to act on aging. We added resveratrol to the exclusive olive polyphenols of the Provitol Complex to take into account an important discovery made with Concordia University. Resveratrol is a modulator of the proteins responsible for cell repair: sirtuins. A recent scientific article reports 244 clinical studies published on this molecule and 27 others still ongoing at the time of its publication in 2019.

Thus, Vitoli Healthy Aging is a product marketed to help you maintain your abilities for as long as possible. It is authorized for sale by Health Canada with NPN800633775 and the claim "Provides antioxidants".

References

• Costantiniet al, 2017. The Greenland shark: A new challenge for the oxidative stress theory of ageing? CompBiochemPhysiol A Mol IntegrPhysiol. 2017 Jan;203:227-232.
• de Pablos et al, 2019. Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immunemediated and neurodegenerative diseases. Pharmacological Research 143 (2019) 58–72.
• Eric Simard, Dr en biologie. 2016. Vivre jeune plus longtemps ; Chapitre 3.2, Les polyphénols d’olives et la diète méditerranéenne. Marcel Broquet la Nouvelle édition. 364 pages.
• Galiniak S, Aebisher D, Bartusik-Aebisher D. Health benefits of resveratrol administration. Acta Biochim Pol. 2019 Feb 28;66(1):13-21. doi: 10.18388/abp.2018_2749. PMID: 30816367.
• Kaeberlein, 2015. Healthy aging: The ultimate preventative medicine. Science, 2015 Dec 4 ;350(6265) :1191-3.
• Menendez et al, 2013. Xenohormetic and anti-aging activity of secoiridoid polyphenols present in extra virgin olive oil. A new family of gerosuppressant agents. Cell Cycle 12:4, 555–578; February 15, 2013.
• Mikhail V. Blagosklonny, 2013. Big mice die young but large animals live longer. AGING, Avril 2013, Vol. 5 No 4.
• Newgard, C.B., Pessin, J.E. 2014. Recent progress in metabolic signaling pathways regulating aging and life span. J Gerontol A Biol Sci Med Sci. Jun;69 Suppl 1:S21-7.
• Peyrolet al, 2017. Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders. Nutrients 2017, 9, 306.
• Singh AP, Singh R, Verma SS, Rai V, Kaschula CH, Maiti P, Gupta SC. Health benefits of resveratrol: Evidence from clinical studies. Med Res Rev. 2019 Sep;39(5):1851-1891. doi: 10.1002/med.21565. Epub 2019 Feb 11. PMID: 30741437.